12 results
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte
 - Causes hyperkalemia?
 - Safe to
hyperkalemia? ... patients with hyperkalemia ... row was removed ... #Crystalloids #pharmacology ... #indications #comparison
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
of Old and New Potassium-Binding ... edgarvlermamd #Potassium ... KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... Binders #Management #Hyperkalemia ... #treatment #pharmacology ... #table #comparison
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... #Binding #Hyperkalemia ... #medications #pharmacology ... #table #comparison
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Lower risk of hypercalcemia ... range - Lack of hypercalcemia ... requirements - Lack of hypercalcemia ... range - Lack of hypercalcemia ... #Comparison #Pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
) - Comparison ... 130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... #comparison #pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
• LDH ↑ • Hyperkalemia ... /Late - Hypercalcemia ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS)

This is a very common pathway that clinicians should
aldosterone which does a lot ... sodium, which causes ... inhibiting drug classes ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... - Hyperkalemia ( ... , in states of hypokalemia ... (or low potassium
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... Bicarb<22) - avoid NS ... emcrit.org/ibcc/hyperkalemia ... management of hyperkalemia ... #Hyperkalemia