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diagnosis hyperkalemia nephrology treatment checklist criticalcare algorithm anesthesia anesthesiology cardiology medications pathophysiology rhabdomyolysis acidosis aniongap chf classification clinical comparison crisis
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #differential # ... pathophysiology #pharmacology ... #potassium #medications
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
Drugs associated ... - Shift from extracellular ... - Insulin (high ... #Medications #differential ... diagnosis #nephrology #Causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... Intracellular Shift ... diagnosis #causes ... #potassium #high
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis Causes of High-anion Gap Acidosis: • Lactic acidosis
Causes of High-anion ... of High-anion Gap ... Drug-induced hyperkalemia ... Potassium-sparing ... Metabolic #Acidosis #differential
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... Intracellular Shift ... diagnosis #causes ... #potassium #high
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... • Treat the cause ... and parenteral potassium ... Intracellular K+ Shift ... #high
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... shift - Acidosis ... Renal failure* - Drugs—potassium-sparing ... #Causes #diagnosis ... #differential
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... Pump - Digoxin works ... intracellular calcium causes ... - Hyperkalemia ( ... high potassium levels
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Drugs (Statins), ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... #Summary #causes
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Summary Causes ... - Toxins - Drugs ... Shift of extracellular ... Monitor potassium
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