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diagnosis treatment differential algorithm nephrology cardiology comparison criticalcare medications pathophysiology rhabdomyolysis table aldosterone angiotensin binders chf clinical crystalloids digoxin druginduced
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Agents to Treat Hyperkalemia ... to moderate); hypokalemia ... Hypomagnesemia; hypokalemia ... #Binding #Hyperkalemia
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... #hyperkalemia ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... • Treat the cause ... treatment leadingto hyperkalemia ... Intracellular K+ Shift ... / Removal #Hyperkalemia
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... works by directly binding ... intracellular calcium causes ... - Hyperkalemia ( ... , in states of hypokalemia
Evaluation and Management of Hypokalemia Hypokalemia is often asymptomatic. Evaluation begins with a search for warning signs
of Hypokalemia ... search for warning signs ... Most cases of hypokalemia-induced ... transcellular shifts ... depletion impedes potassium
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 Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS) This is a very common pathway that clinicians should
sodium, which causes ... inhibiting drug classes ... this pathway, ending ... avoid harmful hyperkalemia ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Summary Causes ... • LDH ↑ • Hyperkalemia ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... emcrit.org/ibcc/hyperkalemia ... of hyperkalemia ... #Hyperkalemia ... #Treatment #potassium
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... #Summary #causes
Pseudohyperkalemia vs Reverse Hyperkalemia Pseudohyperkalemia and reverse pseudohyperkalemia are both conditions where potassium levels appear falsely elevated. Pseudohyperkalemia: This
Pseudohyperkalemia vs Reverse Hyperkalemia ... • No clinical signs ... of hyperkalemia ... No symptoms of hyperkalemia ... Pseudohyperkalemia #Reverse #Hyperkalemia
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