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diagnosis differential nephrology hyperkalemia algorithm management causes tls low oncology framework hyperphosphatemia hypocalcemia hypophosphatemia pathophysiology phosphate rhabdomyolysis tumorlysis uricacid acutekidneyinjury
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor ... Lysis Syndrome ... (TLS) and Treatment ... 8.0 mg/dL • Potassium ... #TumorLysis #Syndrome
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology of Tumor ... Lysis Syndrome ... (TLS) Tumor Cell ... Lysis -> Release ... -> Allantoin (High
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Initial workup ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... #Lysis #Syndrome
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... Renin secreting tumor ... #urine #potassium
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Hyperkalemia: Diagnostic ... transfusion • Tumor ... lysis/hemolysis ... Normal, Renin High ... hypoplasia Aldosterone high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... Transfusion reaction - Tumor ... lysis syndrome ... #high #nephrology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... Presentation #TLS #Workup
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... Intracellular Shift ... Transfusion reaction - Tumor ... lysis syndrome ... #high #nephrology
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... Rhabdomyolysis • Tumor ... lysis syndrome ... glycosides • High ... MCW_Nephrology #HyperKalemia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis Syndrome ... immature blasts and high ... Lysis Syndrome: ... hydration - Hyperkalemia ... #Lysis #Syndrome
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