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Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... Hyperkalemia • Hyperphosphatemia ... Hyperuricemia • Hyponatremia ... Shift of extracellular ... causes #treatment #nephrology
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
- Differential ... Transcellular Shift ... Kidney Disease: • AKI ... CKD Increased Renal ... Workup #phosphate #nephrology
Hypophosphatemia - Differential Diagnosis Algorithm

Transcellular Shift
 • Recovery From DKA
 • Refeeding Syndrome
 • Acute Respiratory
Hypophosphatemia ... - Differential ... Transcellular Shift ... Increased Excretion - Renal ... #LowPhosphate #Differential
Hypophosphatemia - Differential Diagnosis Algorithm
 • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use
 • Redistribution/
Hypophosphatemia ... - Differential ... Redistribution/ Shift ... bone syndrome • Renal ... Algorithm #causes #nephrology
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
- Differential ... Transcellular Shift ... PO4 < 20%: • Renal ... Context of Impaired Renal ... HighPhosphate #Differential
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
- Differential ... Transcellular Shift ... FEPO4 ≥ 5% - Renal ... #Differential # ... Workup #phosphate #nephrology
Hypophosphatemia - Differential Diagnosis Algorithm
Appropriately Low Kidney Phosphate Excretion:
 • Decreased GI Absorption: Chronic Diarrhea, Antacids,
Hypophosphatemia ... - Differential ... Transcellular Shift ... Hyperparathyroidism, TKI ... Diagnosis #Algorithm #nephrology
Hypophosphatemia Diagnostic Algorithm
- GI Losses
- Redistribution
- 1° HPT
- 1° Renal PO4 wasting: Hereditary, TIO, Fanconi Syndrome,
Hypophosphatemia ... - 1° HPT - 1° Renal ... Zalman Agus #Hypophosphatemia ... diagnosis #Algorithm #differential ... #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... Medications Renal ... Losses Non-renal ... Diagnosis #Algorithm #nephrology
Diagnosis and Management of Hyponatremia

#Hyponatremia #Algorithm #Differential #Diagnosis #Management #Nephrology

** GrepMed Recommended Text: Nephrology Secrets -
Diagnosis and Management ... of Hyponatremia ... #Hyponatremia ... #Algorithm #Differential ... #Nephrology