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causes hyperkalemia medications high nephrology rhabdomyolysis table treatment anemia channelblockers classification druginduced hemolytic hypomagnesemia hypomg induced inopressors pathophysiology retention shock
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... Anemia • Hapten (Drug ... Ternary Complex (drug-antibody ... Omeprazole, Sulfa drugs ... #diagnosis #pharmacology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #hyperkalemia #differential ... #pharmacology # ... potassium #medications
Potassium Channel Blockers - Medications 1. Cardiovascular Drugs 2. Psychiatric drugs 3. Other drugs 4. Synthetic opioids: Levomethadyl 5. Opium
Cardiovascular Drugs ... Psychiatric drugs ... Other drugs 4. ... #Medications #Differential ... #Diagnosis #Pharmacology
Shock and Vasoactive Drugs 1) Determine type and etiology of shock • Distributive: Sepsis, Anaphylaxis, Neurogenic
and Vasoactive Drugs ... Understand vasoactive drug ... shock #Vasoactive #Drugs ... inopressors #diagnosis ... #management #comparison
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... Drugs (Statins), ... Shift of extracellular ... Monitor potassium ... #Diagnosis #Management
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
shift - Acidosis ... drugs - Transfusion ... Renal failure* - Drugs—potassium-sparing ... anti-inflammatory drugs ... #differential
Causes of Hypomagnesemia Redistribution: - IV glucose - Correction of diabetic ketoacidosis - IV hyperalimentation - Refeeding
osmotic diuresis - Potassium ... renal disease Drugs ... #differential # ... medications #drugs ... #pharmacology #
Drug-Induced Urinary Retention Drug-induced urinary retention is very common and can be caused by many classes of
Drug-Induced Urinary ... Retention Drug-induced ... acetylcholine (ACh), which binds ... #Induced #differential ... #diagnosis #pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Diagnosis Framework ... reactions Common Drugs ... Intracellular Shift ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... Diagnosis Framework ... reactions Common Drugs ... Intracellular Shift ... #potassium #high
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