22 results
diagnosis hyperkalemia causes medications high nephrology treatment table algorithm blood comparison druginduced drugs hematology product reactions rhabdomyolysis anemia binder channelblockers
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
in Hemolytic Anemia ... complex binds to ... #medications #Hemolytic ... #Anemia #differential ... #diagnosis #pharmacology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... #hyperkalemia #differential
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
Decreased renal potassium ... renal failure • Drugs ... Increased potassium ... • Tumor lysis/hemolysis ... #differential
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... #hyperkalemia #differential
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
) MECHANISM: Potassium ... from other oral drugs ... this from other drugs ... #Binder #KBinder ... #Hyperkalemia #Pharmacology
Potassium Channel Blockers - Medications 1. Cardiovascular Drugs 2. Psychiatric drugs 3. Other drugs 4. Synthetic opioids: Levomethadyl 5. Opium
Potassium Channel ... Other drugs 4. ... Organophosphates #Potassium ... #Medications #Differential ... #Diagnosis #Pharmacology
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... • Consider K+ binder ... Dialysis Serum potassium ... blocks, QRS axis shift ... #hyperkalemia #potassium
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... for Management ... cyclosilicate #Potassium ... #Binders #Management ... Hyperkalemia #treatment #pharmacology
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Tourniquet use - Hemolysis ... shift - Acidosis ... aged blood - Hemolysis ... Renal failure* - Drugs—potassium-sparing ... Causes #diagnosis #differential
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