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diagnosis differential causes hyperkalemia high hypokalemia hypomagnesemia hypomg action algorithm antiarrhythmic cardiology classes druginduced low management nephron pathophysiology rhabdomyolysis sites
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
Summary of Diuretic ... Agents Subclass, Drug ... Chlorthalidone POTASSIUM-SPARING ... #Medications #Pharmacology ... summary #table #nephrology
Diuretics sites of action on the nephron 1) Acetazolamide (carbonic anhydrase inhibitor) 2) Osmotic diuretics (e.g. mannitol) 3) Loop
Diuretics sites ... Metolazone) 5) Potassium-sparing ... diuretics (e.g. ... #pharmacology # ... nephrology #medications
Classification of Diuretics #pharmacology #nephrology #classification #drugs
Classification of ... Diuretics #pharmacology ... #nephrology #classification ... #drugs
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Transcellular Shift ... Thyrotoxicosis Medications ... • Discontinued diuretic ... Diagnosis #Algorithm #nephrology ... #low #potassium
Antiarrhythmic Drugs CLASS IA • Procainamide, Quinidine, Disopyramide CLASS 1B • Lidocaine, Mexiletine CLASS 2 • Propranolol, Esmolol CLASS 4
Antiarrhythmic Drugs ... Adenosine, Magnesium, Potassium ... Antiarrhythmic #Medications ... #Classes #Classification ... #Pharmacology #
Drugs associated with hypokalemia and hypomagnesemia Hypokalemia - Shift from extracellular fluid to intracellular fluid compartment -
Drugs associated ... Hypokalemia - Shift ... foscarnet - Diuretics ... hypomagnesemia #Medications ... differential #diagnosis #nephrology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... pathophysiology #pharmacology ... #potassium #medications
Causes of Hypomagnesemia Redistribution: - IV glucose - Correction of diabetic ketoacidosis - IV hyperalimentation - Refeeding
- Potassium depletion ... renal disease Drugs ... : - Loop diuretics ... #differential #medications ... #drugs #pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
reactions Common Drugs ... • K sparing diuretics ... Intracellular Shift ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
reactions Common Drugs ... • K sparing diuretics ... Intracellular Shift ... Medications 2. ... #high #nephrology
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