49 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Syndrome • ... SyndromeClinically ... Diagnosis and Treatment ... #Hematology #eosinophilia ... eosinophils #diagnosis #management
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... eosinophilia (common causes ... glucocorticoid treatment ... symptoms (eg, skin ... Differential #diagnosis #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... adsorption onto cancer ... vonWillebrand #Syndrome ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... Myelodysplastic #Syndrome ... #treatment #hematology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... Syndrome (HES) ... than 1500 and clinical ... eosinophilia Secondary Causes ... eosinophilia #diagnosis #hematology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Causes: - Idiopathic ... - Underlying cancer ... - Hematologic cancer ... Treatment: - Systemic ... #diagnosis #dermatology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
thermoregulatory center ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... loss from the skin ... comparison #diagnosis #management
When to look for clonal/neoplastic hypereosinophilia (HEo)?
 - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
clonal/neoplastic hypereosinophilia ... Exclusion of frequent causes ... helminthiasis, cancer ... ) - Clinical symptoms ... Diagnosis #Signs #Hematology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... refractory disease Skin ... Behcets #disease #Syndrome ... #Treatment #management ... #pharmacology #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... Rarely dominate the clinical ... • Goodpasture syndrome ... rash #diagnosis #rheumatology