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differential management systemic erythematosus pulmonary sle arthritis causes primary sclerosis syndrome vasculitis addisons adrenal aids arteritis autoantibodies behcet borreliosis bronchiectasis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Myositis 4% - Lung ... sclerosis, Still's disease ... autoantibodies #signs ... #symptoms #mimickers ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
accompanies other autoimmune ... RA) or systemic lupus ... erythematosus (SLE) Signs ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Sarcoidosis Non-caseating granulomas (Composed of T-helper & inflammatory cells) Clinical: • Disease fatal in 10% of
Clinical: • Disease ... exertion • Neurologic ... Subcutaneous nodules, lupus ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... skin thickening Signs ... (interstitial lung ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Adrenals: • Lung ... vomiting • Fatigue Signs ... Cortisol Deficiency: Signs ... Reduced libido • Signs ... #signs #symptoms
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Myositis, Comorbid autoimmune ... disorders (Systemic lupus ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Non-autoimmune ... rheumatologic diseases ... : • Symptoms limited ... #Rheumatology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Toxoplasmosis AUTOIMMUNE ... - Systemic Lupus ... syndrome (bulbar symptoms ... - small cell lung ... #Causes #Neurology
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