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diagnosis differential algorithm aki antibodies classification dermatology nephrology workup acutekidneyinjury ana antibody antineutrophil antinuclear associations autoantibodies cryoglobulinemia cryoglobulins erythematosus glomerulonephritis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Vasculitis: • ... Microscopic polyangiitis ... Renal-limited vasculitis ... antibodies #diagnosis #rheumatology ... #diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-LKM (liver kidney ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... tract, and often causes ... purpura: strong sign ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... dipstick, urine microscopy ... clinical context and signs ... Glomerulonephritis / Vasculits ... : ANCA, ANA, Anti-GBM
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... • Limited to Kidney ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... Von Willebrand disease ... - APLS • Acute ... Cryoglobulinemia (MIXED) • ANCA ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... musculoskeletal systems • Kidneys ... )): Microscopic ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Guide to Acute Kidney Injury (AKI) What to ask/look for: - HPI, PMH, full ROS
Guide to Acute Kidney ... - Urinalysis/microscopy ... rhabdo/TLS) Causes ... - Pre-renal disease ... Glomerulonephritis or vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Non-autoimmune rheumatologic ... Pleural effusions • Acute ... C4) • ds-DNA: Kidney ... induced SLE • Kidney
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... classification #rheumatology
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