15 results
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... PR3 Anti-GBM disease ... vasculitis - MPO ... #Associated #Vasculitis ... #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
- Anti-U1-RNP ANCA-Associated ... Microscopic polyangiitis ... - MPO>PR3 - ANCA ... disease - MPO>PR3 ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: ANCA Associated ... Hydralazine-Induced ANCA-Associated ... Vasculitis: + MPO-ANCA ... Diagnosis: Systemic rheumatic ... purpura: strong sign
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
hepatitis Anti-CCP, Rheumatoid ... c-ANCA - Vasculitis ... - Vasculitis, e.g ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Glomerulonephritis • With associated ... involvement: Anti-GBM Disease ... MPO-ANCA (P-ANCA ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
 • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Nodosa (PAN), ANCA ... associated vasculitis ... (rare) • Rheumatic ... (IgG4-RD), Rheumatoid ... Differential #Diagnosis #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
polyangiitis, Microscopic ... vasculitis (IgA-associated ... vasculitis, Behcet ... erythematosus, Rheumatoid ... testing: anti-ANCA
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of Vasculitis ... Vasculitis of ... small vessels - ANCA-associated ... granulomatosis - microscopic ... Vessels #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Rheumatic Diseases ... are associated ... • Rheumatic Diseases ... #patterns #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis: • Systemic rheumatic ... purpura: Strong sign ... : ANCA Associated ... myeloperoxidase (MPO-ANCA ... )): Microscopic