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diagnosis differential arthritis antibodies classification dermatology joint pain symptoms ana antinuclear skin syndrome antibody antineutrophil aortitis associated associations autoantibodies canca
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... c-ANCA - Vasculitis ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Scleritis, Heart Disease ... , Rheumatoid Vasculitis ... , Pulmonary Disease ... #diagnosis #rheumatology ... #signs #symptoms
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Nodosa (PAN), ANCA ... Diseases: IgG4- ... Related Disease ... Arthritis (RA),
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
Vasculitis A group ... polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... PR3 Anti-GBM disease ... PR3 #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Microscopic polyangiitis ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... diseases, such ... atherosclerotic disease ... most important diseases
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
- Kawasaki disease ... small vessels - ANCA-associated ... granulomatosis - microscopic ... and infectious diseases ... Vessels #Diagnosis #Rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... polyangiitis, Microscopic ... disease, Cryoglobulinemia ... Goodpasture's Disease ... dysmorphic RBCs) • Disease-specific
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Disease! ... diseases, but often ... • Rheumatic Diseases ... #patterns #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Secondary: CTD: SLE, RA ... • ANCA Associated ... : - Microscopic ... : • Behcet Disease ... #dermatology #rheumatology
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