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hematology causes hemolysis algorithm extravascular intravascular acidosis aki classification dehydrogenase elevated elevation hemolytic index injury kidney laboratory lactic ldh medications
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing Acute ... tenofovir • AIN: Beta-lactams ... sphincter tone: • Opiates ... #pharmacology # ... differential #diagnosis
Primary Dermatologic Nail Disorders - Differential Diagnosis Algorithm Nail Plate - Pitting • Psoriasis • Alopecia Areata Nail
Primary Dermatologic ... Nail Disorders - Differential ... Diagnosis Algorithm ... Under Nails • Drug-Induced ... Trauma/lnfection - Acute
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate ... #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Hemolysis within circulation ... immune-complex hemolytic anemia ... • Acute HTR ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
suppression (e.g. drugs ... Index > 3: • Acute ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... Injury: • Early acute ... hepatitis • Acute
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... If drugs, seizures ... cardiac output - Acute ... peritonitis - Acute ... 30mmHg) - Severe anemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... infection) - Drugs ... (Beta lactam antibiotics ... Extravascular #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - Hemolytic anemia ... - APLS • Acute ... #Diagnosis #hematology
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