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differential management toxicity aki classification nephrology algorithm amiodarone aspirin clozapine dili druginduced elderly elevation ferrous geriatrics hepatology high hyperkalemia hypokalemia
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing Acute ... Kidney Injury ( ... sphincter tone: • Opiates ... #pharmacology # ... differential #diagnosis
Vancomycin Associated Acute Kidney Injury • Drug induced acute kidney injury is generally defined as a
• Drug induced ... acute kidney injury ... • Treatment includes ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis
Salicylate Toxicity - Diagnosis and Management Consider if: 1) Patient is hot and altered 2) You see tachypnea with
Salicylate Toxicity - Diagnosis ... no respiratory cause ... 5) History of acute ... Aspirin #Toxicity #Toxicology ... #Treatment
Acute Iron Poisoning There are five classically described phases of toxicity: Gastrointestinal phase (~6 hours post-ingestion) -
Acute Iron Poisoning ... caustic mucosal injury ... Abdominal pain, nausea ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... /HDS treatments ... for alternative causes ... dechallenge • Acute ... #Diagnosis #Algorithm
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
liver or renal injury ... circulation If drugs ... before beginning treatment ... cardiac output - Acute ... peritonitis - Acute
Clozapine Toxicology Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... antipsychotic drugs ... Clozapine is known to cause ... #Toxicity #Diagnosis ... #Pharmacology
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... Renal tubular acidosis ... Conn's, Liddle's), Drugs ... Hypomagnesemia, Acute ... #differential #diagnosis
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... Acidosis B. ... neuromuscular injury ... injury F. ... #Differential #Diagnosis
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
cytotoxic lung injury ... pleural effusions • Acute ... toxicity (e.g., acute ... Exclude other causes ... #management #Toxicology
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