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differential algorithm aki classification elevation emesis endocarditis hematology kidneyinjury management nephrology vomiting abdominal acidosis aplastic calculation chronic ck creatine ctchest
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
sphincter tone: • Opiates ... decongestants) • Any drug ... #Medications #Drugs ... #pharmacology # ... differential #diagnosis
Common causes of Acute Kidney Injury AKI - Differential Diagnosis HEMODYNAMIC • Cardiac failure: Impaired forward flow,
Common causes of ... Acute Kidney Injury ... systemic disease or drugs ... hypotension • Drugs ... Nephritis (AIN) • Drugs
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Reticulocyte Production Index ... appropriately)- Retic Index ... . drugs, chemotherapy ... > 3: • Acute ... #differential #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... exposure to HDS, drugs ... non-essential drug ... for alternative causes ... dechallenge • Acute
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Hematologic • Anemia ... Myasthenia Gravis Pharmacologic ... Anti-Depressants • Drug ... Alcohol) • Drug ... Malnutrition / Drug
Simplified Approach to Acute Kidney Injury (AKI) 1) IS THIS AN EMERGENCY? Is there a dialysis indication
Simplified Approach to Acute ... Kidney Injury ( ... AEIOU ) or anuria ... obstruction, Nephrotoxic drugs ... are caused by prerenal
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Causes of Pericardial ... - Differential Diagnosis ... • Metabolic: Uremia ... Dissection, Idiopathic, Drug-related ... #Causes #cardiology
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Causes of Acute ... induced (select drugs ... pericarditis) Uremia ... Rheumatic fever #Causes ... #Differential #Diagnosis
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 Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... and petechiae Causes ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... • Reticulocyte index
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Creatine Kinase - Causes ... Elevated CK Levels Acute ... RHABDOMYOLYSIS - Drugs ... renal injury, Strenuous ... #differential #diagnosis
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