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management rheumatology differential hepatology liver oncology transaminitis workup causes chemistry chronic cll dermatology laboratory leukemia lymphocytic activation algorithm alkphos anemia
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... pathology (low level ... Liver #Enzymes #LFTs ... Transaminitis #diagnosis ... #differential #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Transaminase Levels ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
with higher CK levels ... , greater level ... /full triad at diagnosis ... after 2 years of treatment ... #rheumatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
• Increased levels ... AlkPhos #Bilirubin #Hepatology ... Pathophysiology #Diagnosis ... #LFTs
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
factor activity levels ... Classify severity Treatment ... by a hemophilia treatment ... #Management #treatment ... #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... function tests (LFTs ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
time • Reduced levels ... II • Reduced levels ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... ) B symptoms → fevers ... transformation) Treatment ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... , ↓ Fibrinogen level ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
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