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Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
Therapeutic Target Levels ... lithium, target levels ... vary depending on treatment ... mortality at a higher level ... #Pharmacology #Diagnosis
Diagnosis Adrenal Insufficiency - Algorithm

Step 1) Screening Test: 6-8AM Cortisol Level
 - Early morning cortisol levels
Diagnosis Adrenal ... 6-8AM Cortisol Level ... - Levels > 15 ... lower, you have diagnosed ... Insufficiency #Algorithm #Diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
function below injury level ... Sensory loss below level ... motor function, level ... and #Acute #SpinalCord ... Injury #Syndromes #diagnosis
Spinal Cord Injury by Nerve Root Levels
Spinal Root	Sensory	Motor	Reflex
C4	Acromioclavicular Joint	Respiration	None
C5	Radial Antecubital Fossa	Elbow Flexion	Biceps Reflex
C6	Dorsal Thumb	Wrist Extension	Brachioradialis Reflex
C7	Dorsal
by Nerve Root Levels ... Sphincter None #SpinalCord ... Injury #NerveRoots #Levels ... #differential #diagnosis
Incomplete Spinal Cord Syndromes
Anterior Cord Syndrome:
 • Bilateral loss of motor, pain and temperature sensation below
sensation below level ... #Incomplete #SpinalCord ... #Syndromes #Diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
with higher CK levels ... , greater level ... /full triad at diagnosis ... after 2 years of treatment ... Autoimmune #Myositis #diagnosis
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
- Differential Diagnosis ... Pain reported at level ... (1-5 levels below ... #spinal #cord #spinalcord ... #disorders #diagnosis
Carbon Monoxide Poisoning

Symptoms are non-specific:
 - Headache 90%
 - Nausea/vomiting 50%
 - Vertigo 50%
 - Altered
Subjective weakness 20% Diagnosis ... Alarm (for CO levels ... measuring COHb levels ... Treatment: 100% ... Poisoning #Toxicology #diagnosis
Incomplete spinal cord syndromes (ISCS)
 • Central - Small Lesion - Suspended sensory deficit, classic cape
LMN deficit at level ... sensory deficits at level ... ISCS #Incomplete #spinalcord ... #syndromes #diagnosis
Myotomes of the Spinal Cord
Each segmental nerve root innervates more than one muscle. For simplicity, certain
#Myotomes #SpinalCord ... #Diagnosis #Neurology