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diagnosis causes hematology anemia algorithm extravascular high hyperkalemia intravascular nephrology potassium dermatology g6pd geriatrics hyponatremia list nonpalpable palpable purpura rheumatology
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... atypical HUS) - Drug-induced ... • Severe B12 deficiency ... • Mechanical hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... delayed HTR • Drug-induced ... Intravascular - Hemolysis ... • PNH • Drug-induced
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... #medications #Hemolytic ... #table
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... autoimmune disease, drugs ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... infection) - Drugs ... G6PD deficiency)
Drug-induced Hemolysis in G6PD Deficiency Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... #DrugInduced #Hemolysis ... #Pharmacology # ... Differential #Diagnosis ... #Table #Medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... edema • Jaundice/Hemolytic ... reactions Common Drugs ... cell lysis: - Hemolysis ... Medications 2.
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... edema • Jaundice/Hemolytic ... reactions Common Drugs ... cell lysis: - Hemolysis ... Medications 2.
Numerous drugs taken by elderly persons can affect water balance by direct action on the kidney
Numerous drugs taken ... on the kidney (Table ... #Diagnosis #Pharmacology ... #DrugInduced #List ... #Differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Secondary Causes: - Drug ... /TTP/HUS - Hemolytic ... necrosis) • VIT K deficiency ... spotted fever • Drug
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