498 results
diagnosis differential hematology algorithm causes management clinical pathophysiology workup symptoms signs hemolytic nephrology neurology cardiology pharmacology comparison thrombocytopenia treatment table
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis Platelet ... Reactive: • Anemia ... trauma) • Post-splenectomy ... Diagnosis #causes #Platelets
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... hemolysis, deficiency anemia ... Asplenia/post-splenectomy ... Thrombocytosis #Platelets
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
children) • Platelets ... extremely low platelet ... immunoglobulin • Splenectomy
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... phenotype, Post-splenectomy ... Hemoglobinopathies, Post-splenectomy ... autoimmune hemolytic anemia
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Autoimmune Hemolytic Anemia ... DIAGNOSE AIHA • Anemia ... Rituximab +++ 3 - Splenectomy ... Autoimmune #Hemolytic #Anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Megaloblastic anemia ... , Pernicious anemia ... intoxication, Post-splenectomy
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Severe hemolytic anemia ... Sideroblastic anemia ... , Hemolytic anemia ... , Post-splenectomy
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Immunosuppression, Splenectomy ... Autoimmune Hemolytic Anemia ... Autoimmune #Hemolytic #Anemia
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... ristocetin • Normal platelet ... count and platelet ... • Platelet flow ... Usually normal platelet
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