36 results
diagnosis hematology differential management algorithm anemia thrombocytosis classification leukemia nutrition cll folate lymphocytic mcv mds microcytic myelodysplastic platelets syndrome alopecia
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
blood loss (Fe deficiency ... Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic ... Differential #Diagnosis #causes ... #Platelets #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... 80 fL) • Iron Deficiency ... • Folate Deficiency ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... : • Acute or Chronic ... effect following treatment ... malignancy • Iron deficiency ... #Hematology
Diagnosing Vitamin B12 and/or Folate Deficiency It turns out that simply measuring serum levels of B12 or
and/or Folate Deficiency ... with low B12 stores ... normal tissue stores ... tissue folate stores ... Diagnosis #Nutrition #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... specifically: iron deficiency ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... #hematology #secondary
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Etiologies of Folate Deficiency ... folate that can cause ... mobilize folate stores ... depleted tissue stores ... differential #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
• Anemia of chronic ... • Anemia of chronic ... , Folate deficiency ... differential #diagnosis #causes ... #hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Treatment of Thrombotic ... severe, ADAMTS13 deficiency ... PLEX and RTX • Short-term ... #rheumatology # ... hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Acute hemolysis, deficiency ... Rebound effect from treatment ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • B12/Folate Deficiency ... • Anemia of Chronic ... Diagnosis #Algorithm #Causes ... #Hematology
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