14 results
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis) - ANCA-negative ... vasculitis (IgA-associated ... testing: anti-ANCA ... , anti-GBM ab, ANA
A System for Vasculitides 

#Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
#Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential ... Associated - ANCA ... Hydralazine-Induced ANCA-Associated ... LFT • ESR • ANA ... #rheumatology #classification
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Mimics - Differential ... Diagnosis Framework Diffuse ... glomerulonephritis 90%: - ANCA ... Associated Vasculitis ... Double Positive (ANCA
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... #diagnosis #algorithm
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... Associated Rheumatic ... • Nucleolar: Diffuse ... Antinuclear #Antibodies #ANA ... rheumatology #diagnosis #differential
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated ... or clinically) and ... StanfordChiefs #ANCA ... #Vasculitis #differential ... #diagnosis #algorithm
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
• +ANA can be seen ... Patterns and Associated ... • Nucleolar: Diffuse ... with a +ANA? ... rheumatology #diagnosis #differential
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... ESR, Normal CK, associated ... Lupus Myopathy • Diffuse ... joint aches • +ANA ... Myopathies #myopathy #differential
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Diagnosis Algorithm ... lymphadenopathy more diffuse ... Lymphoproliferative #Disorders #Classification ... #algorithm