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differential antinuclear autoantibodies systemic antibody antineutrophil classification connectivetissuediseases ild management myopathy myositis sle tafro thrombocytopenia vasculitides
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... Ill • ANCA Vasculitis ... #diagnosis #associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... La) - Sjogren's syndrome ... c-ANCA - Vasculitis ... #diseases #diagnosis ... #table #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANA ≠ Autoimmune ... : The ANA patterns ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
PSS: Sjogren syndrome ... #CTILD #Diagnosis ... #Table #Pulmonary ... #Rheumatology # ... Associations
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... cases • Sjögren syndrome ... Jcortesizaguirr #ANA ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ACLE) • Erythematous ... rheumatologic diseases ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Mucocutaneous lymph node syndrome ... : • Behçet Syndrome ... • Cogan Syndrome ... ) pattern: antibodies ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... searched for when ANA ... SLE-SSc-AlM overlap syndromes ... #diagnosis #rheumatology ... #table #ANA
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• Anti-NXP2 (ANA ... (ANA present 80% ... Antisynthetase syndrome ... or head drop • ANA ... Myositis #Myopathy #rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
TAFRO TAFRO syndrome ... including systemic lupus ... erythematosus ( ... , ANCA-associated ... #management #rheumatology
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