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Thyroid Function Pathway 

Hypothyroidism is a very common condition! Here's a repost of the pathway that
Thyroid Function ... stimulate more T4/T3 ... /ambcarerx #Thyroid ... #Pathway #Pathophysiology
Thyrotoxic Periodic Paralysis - Illness Script
 • Epidemiology: Asian men age 20-30 with hyperthyroidism of any
and menses • Pathophysiology ... pump by excess thyroid ... high fT4 or high T3
Thyroid Function Tests (TFTs) and Interpretation

 • TSH, Free T4, Free T3
 • T3 Uptake
 •
Thyroid Function ... Free T4, Free T3 ... • T3 Uptake ... FTI) • Reverse T3 ... @DharSaty #Thyroid
Laboratory Evaluation of Patients for Thyroid Disease 
Hyperthyroidism:
 • Graves disease - TSH low; free T4
of Patients for Thyroid ... iodine uptake; thyroid ... iodine uptake; thyroid ... procedure that ablates thyroid ... concentrations of TSH and thyroid
Pharmaceutical Management of Hyperthyroidism / Thyroid Storm
Beta-Blockers 
• Decreases sympathetic hyperactivity 
• Partially blocks peripheral conversion
Hyperthyroidism / Thyroid ... conversion of T4 to T3 ... Blocks synthesis of thyroid ... conversion of T4 to T3 ... conversion ofT4 to T3
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
thyrotoxicosis • T3 ... TSH • ↑ Total T3 ... ↑ Free T4 • Thyroid ... ↑ FT4 and/or ↑ T3 ... : Reduce T4 -> T3
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism
 • Low TSH, Low normal T4
Approach to Thyroid ... normal T4 +/- T3 ... TSH, high T4 +/- T3 ... symmetrically enlarged thyroid ... TSH, high T4 +/- T3
Thyroid Function Test Interpretation Table

TSH, Free T4, Free T3 and Associated Condition
#Diagnosis #Endocrinology #Hyperthyroid #Hypothyroid #Function
Thyroid Function ... Free T4, Free T3
Algorithm for the diagnostic workup of hyperthyroidism. (T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid-stimulating
(T3 = triiodothyronine ... thyroxine; TSH = thyroid-stimulating
Amiodarone Thyroid Complications
Amiodarone: 
 - iodine-rich, similar structure to T4, with half life up to 100d
Amiodarone Thyroid ... conversion ofT4 to T3 ... can prevent T4/T3 ... directly toxic to thyroid ... pts w/ latent thyroid