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diagnosis nephrology renal acute akd aki algorithm biomarkers causes chronic clock differential hepatology hepatorenal hrs hrsaki hrsckd hrsnaki hyperkalemia k
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
• GFR < 60 ml/min ... • AKI, OR • GFR ... • Decrease in GFR ... • GFR ≥ 60 ml/min ... #AKD #Definitions
The GFR Clock for Staging CKD Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... as a proxy for kidney ... filtered in the kidney ... Using the GFR clock ... #EGFR #Staging
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
Interpreting Kidney ... Creatinine: • AKI, CKD ... nephroprotective ↓ in GFR ... Cystatin C: • AKI, CKD ... #Biomarkers #Kidney
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
maintaining baseline GFR ... setting of modest GFR ... use in CKD with ... GFR > 30 and complete ... avoidance with GFR
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
e.g. diuretics, NSAIDs ... No structural kidney ... months - eGFR ... ascites • HRS-CKD ... - eGFR < 60ml
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Causes of Chronic Kidney ... function (eGFR ... eosinophiluria) • Drugs (NSAlDs ... ) • Multiple myeloma ... Hyperphosphatemia #CKD
Chronic Kidney Disease (CKD): Individualize BP-lowering therapy and treatment targets in people with frailty, high risk of
Chronic Kidney Disease ... (CKD): Individualize ... Initial dips in eGFR ... GFR reductions of ... #CKD #eGFR #Kidney
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
K+, ACEi/ARBs, NSAIDs ... esp w oliguria / GFR ... Labs: BMP (Assess GFR ... status to improve GFR ... sufficient if intact GFR
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