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diagnosis kidney renal biomarkers definitions differential framework hepatology hepatorenal hrs hyperkalemia hyperphosphatemia k laboratory management nsaids pharmacology potassium prostaglandins syndrome
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
, CKD, AKD Acute ... ): • GFR < 60 ... • GFR < 60 ml/min ... ): • GFR ≥ 60 ... #nephrology #acute
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI ... , CKD • Medications ... nephroprotective ↓ in GFR ... , CKD • Obesity ... hyperthyroidism ↓ eGFR
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
t-PA, heparin Acute ... Kidney Disease: • AKI ... , CKD Increased ... Hypoparathyroidism, Acromegaly, FGFR ... #nephrology
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
is increased in CKD ... maintaining baseline GFR ... setting of modest GFR ... with GFR > 30 and ... avoidance with GFR
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
esp w oliguria / GFR ... Labs: BMP (Assess GFR ... status to improve GFR ... sufficient if intact GFR ... Treatment #potassium #nephrology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
hepatitis, or acute ... dominates → ↓ GFR ... Exclude other AKI ... Classification: HRS-AKI ... HRS-Non-AKI (formerly
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