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nephrology diagnosis kidney pharmacology akd biomarkers comparison definitions differential effects framework hepatology hepatorenal hrs hrsaki hrsckd hrsnaki hyperkalemia hyperphosphatemia k
Definitions of AKI, CKD, AKD Acute Kidney Injury (AKI): • Increase in SCr by 2 50% within
, CKD, AKD Acute ... ): • GFR < 60 ... • GFR < 60 ml/min ... • Decrease in GFR ... ): • GFR ≥ 60
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI ... , CKD • Medications ... nephroprotective ↓ in GFR ... , CKD • Obesity ... hyperthyroidism ↓ eGFR
Effects of Prostaglandins and NSAIDs on the Kidney Effects of Prostaglandins on the Kidney: • The vasodilatory
perfusion of remaining nephrons ... maintaining baseline GFR ... setting of modest GFR ... with GFR > 30 and ... avoidance with GFR
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Diagnostic Criteria HRS-AKI ... haematuria, Normal renal ... Type 2) • HRS-AKD ... months - eGFR ... - eGFR < 60ml
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
t-PA, heparin Acute ... Kidney Disease: • AKI ... , CKD Increased ... Renal Phosphate ... Hypoparathyroidism, Acromegaly, FGFR
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
states such as acute ... Saline Causes AKI ... signal to reduce GFR ... filtration - Renal ... - Decreased GFR
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
esp w oliguria / GFR ... , RTA Type IV, AI ... Labs: BMP (Assess GFR ... status to improve GFR ... sufficient if intact GFR
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