10 results
Summary of dosing recommendations in renal impairment of commonly used hypoglycaemic agents

#Diabetes #Diabetic #Medications #Pharmacology #Dosing
hypoglycaemic agents #Diabetes ... #Diabetic #Medications ... #Pharmacology # ... Renal #Impairment #CKD ... #Table #GFR #Hypoglycemics
Adjusted Pain Medication Dosing based on GFR

#Renal #Dosing #Pain #Pharmacology #Opiates #CKD #Gabapentin #Table
Dosing based on GFR ... #Dosing #Pain #Pharmacology ... #Opiates #CKD #
Effects of Prostaglandins and NSAIDs on the Kidney
Effects of Prostaglandins on the Kidney:
 • The vasodilatory
maintaining baseline GFR ... setting of modest GFR ... with GFR > 30 and ... avoidance with GFR ... renal #nephrology #pharmacology
Estimating the Total Daily Dose (TDD) of Insulin: Weight-Based Dosing
TDD in units of insulin = N
(stage IV or V CKD ... including most type 1 diabetics ... including most 2 diabetics ... Weight #Based #pharmacology ... endocrinology #diabetes
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
, & an eGFR ≥ 30 ... evidence-based pharmacologic ... #Diabetes #CKD # ... ADA #KDIGO #eGFR ... #Insulin #metformin
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... cells, triggering insulin ... contraindicated in CKD ... Sulfonylureas #Pharmacology ... #Summary #DM2 #diabetes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
esp w oliguria / GFR ... Labs: BMP (Assess GFR ... VBG (acidosis), CK ... status to improve GFR ... sufficient if intact GFR
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... #Metformin #CKD ... #pharmacology #
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... • Increases insulin-mediated ... not initiate if eGFR ... #Metformin #Pharmacology ... #Summary #DM2 #diabetes
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm
Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
kidney function (eGFR ... Proteinuria) • Diabetes ... ) • Multiple myeloma ... Hyperphosphatemia #CKD