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Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
• Uric

Lysis Syndrome (TLS ... Abnormalities of TLS ... Laboratory TLS ... mg/dL Clinical TLS ... Treatment of TLS

Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,

lysis syndrome (TLS ... cytotoxic therapy of ALL ... TumorLysis #syndrome #TLS

Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
• Purines -> Hypoxanthine /

Lysis Syndrome (TLS ... TumorLysis #Syndrome #TLS

Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,

Lysis Syndrome (TLS ... Pathophysiology Culprits: ALL ... Burkitt, SCLC Cells all ... Lysis #Syndrome #TLS

Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider

Treatment of Clinical TLS ... MatthewHoMD #TLS

Crystal cast in patient with AKI and TLS on Urine Microscopy

Randy Luciano MD, PhD @RandyLucianoMD

#TLS #Crystal

patient with AKI and TLS ... RandyLucianoMD #TLS

Tongue Fasciculations in ALS

Martín Hunter MD @interconsulta

#Tongue #Fasciculations #als #amyotrophic #lateral #sclerosis #neurology #physicalexam #clinical #video

Fasciculations in ALS ... Fasciculations #als

Jaw-Jerk Reflex Clonus in ALS

- Neurology Pro - A DDx Tool @ProDdx

#JawJerk #Jaw #Jerk #Reflex #Clonus

Reflex Clonus in ALS ... Reflex #Clonus #ALS

Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
• Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity

: - Neuro: AMS ... have fever - ACS ... leukapheresis - TLS ... Lysis #Syndrome #TLS

Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of

#Presentation #TLS

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