13 results
Evaluation of Patients with Anemia

Microcytic, Normocytic, Macrocytic, Hemolytic (Intravascular and Extravascular)

#Diagnosis #Anemia #Workup #Macrocytic #Microcytic #Normocytic
Patients with Anemia ... , Macrocytic, Hemolytic ... (Intravascular ... and Extravascular ... Anemia #Workup #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... #Hemolytic #Intravascular ... #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
and Intravascular ... Hemolysis - Differential ... Diagnosis Algorithm ... anemia • ... Differential #Diagnosis
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Morphology Atlas • Microcytic ... Lead poisoning • Macrocytic ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... , Disseminated intravascular
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
to Anemia - Differential ... by MCV Microcytic ... -100): • Non-hemolytic ... , CKD • Hemolytic ... Diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
) Morphology Microcytic ... (sometimes) Macrocytic ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Diagnosis Algorithm ... Hypochromic & microcytic ... #Anemia #Differential ... #Diagnosis #Algorithm
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... (not extravascular ... ) hemolysis, Intensive ... #Anemia #Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Diagnosis Algorithm ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... causing intravascular ... #hemolytic #anemia