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differential liver management transaminitis interpretation blood function gastroenterology hematology product reactions tests aclf alcoholic chemistry chest chronic cirrhosis complications drug
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
(LFTs) - Differential ... Hepatopathy • Acute ... (>1000): • DILI ... #LFTs #Differential ... #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... #differential #Diagnosis ... gastroenterology #algorithm ... gastroenterology #hepatology
Pulmonary Function Tests (PFTs) - Interpretation Algorithm • Normal • Pulmonary Hypertension, Anemia, Carboxyhemoglobinemia • Chest
Tests (PFTs) - ... Interpretation Algorithm ... • Interstitial Lung ... FunctionTests #PFTs ... #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... for alternative causes ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... #FunctionTest #LFTs ... Transaminitis #diagnosis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... > 20x normal - Acute ... Patterns #Liver #Injury ... #hepatology #LFTs ... #differential #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Causes of Acute ... CA, small cell lung ... #diagnosis #algorithm ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Brain Failure Lung ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
→ liver test abnormalities ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... viral hepatitis ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
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