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diagnosis hepatology aki lfts causes transaminitis algorithm classification tests chemistry failure function hepatitis interpretation lactate management acidosis aclf acutekidneyinjury alkphos
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... • AST/ALT elevation ... skeletal muscle and kidney ... Transaminitis #diagnosis #differential ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Liver Injury: ... extrahepatic source - Tests ... #differential #
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... skeletal muscle, kidney ... Hepatocellular injury ... 2: Cholestatic injury
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... Enzyme Elevation ... Cardiac muscle, Kidneys ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... hepatocellular injury ... #Function #Tests ... #LFTs #Laboratory ... Interpretation #diagnosis #hepatology
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Pigment, Protein) • AIN ... #Kidney #Injury ... Diagnosis #nephrology
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... cardiorenal syndrome) • Liver ... interstitial nephritis (AIN ... #Kidney #Injury ... Classification #diagnosis #nephrology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... injury) • Ischemic ... #Diagnosis #hepatology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Acute Kidney Injury ... change disease • Hematologic ... #Kidney #Injury ... Cancer #Oncology #Differential ... Classification #Nephrology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Circulation Failure Kidney ... Alcohol-Associated Hepatitis (AAH ... Injury (DILI) ... Failure #Cirrhosis #Hepatology
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