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diagnosis hepatology algorithm causes transaminitis treatment hepatitis rheumatology workup aki blood classification failure function gastroenterology interpretation kidney lactate product reactions
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Hepatopathy • Acute ... injury) • Ischemic ... #LFTs #Differential ... #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... test abnormalities ... Injury Differential ... #Injury #Differential
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... injury - Viral ... hepatitis - Wilson disease ... #Causes #Differential ... #Hepatology #Diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... #differential # ... gastroenterology #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... hepatocellular injury ... #Function #Tests ... #LFTs #Laboratory
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... Syndrome, Celiac Disease ... #Injury #Differential ... #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... of cholestatic disease ... disease: > 2 ... chemistry #diagnosis #differential ... #LFTs #RValue #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Liver Injury: ... extrahepatic source - Tests ... #differential #
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
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