18 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... gastric bypass), LFT ... (liver disease) ... #Workup #hematology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
CMV), Alcoholic cirrhosis ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #hepatology #LiverFunctionTests
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... fibrin-split products - Thrombocytopenia ... deficiency - Anemia ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... Blood Smear ↑ abnormal ... #Diagnosis #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
the spleen or liver ... also arise in normal ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
/Liver failure ... or higher • Liver ... bile ducts Differential ... Endocrinopathy, Lymphoma ... #workup #hepatology
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
Differential Diagnosis ... , Inflammation NORMAL ... splenomegaly, Thrombocytopenia ... #Cirrhosis #Differential ... #Diagnosis #Hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... for Thrombotic Thrombocytopenic ... result in severe anemia ... WBC count and differential ... #Workup #Hematology