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differential management algorithm classification cryoglobulinemia cryoglobulins erythematosus framework hemophagocytic hlh hus icl idiopathic leukemia lupus lymphocytopenia lymphohistiocytosis lymphopenia microangiopathy myopathy
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs Autoimmune ... • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... : ITP, HITT - Autoimmune ... : SLE, RA, antiphospholipid ... syndrome - Pregnancy ... #Framework #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
occasions COMMON ASSOCIATIONS ... Autoimmune (Sjogren ... , SLE, Kikuchi dz ... #hematology #Differential ... #Causes #lymphocytopenia
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
almost) all TMAs cause ... triad of MAHA + thrombocytopenia ... . 5. 2nd TMA- autoimmune ... Microangiopathy #TMAs #hematology ... #diagnosis #ttp
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... • Low serum C4 ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... /aggregate) of CD4 ... and peripheral Thyroid ... phenomenon (16%) MSK ... #Rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... disease • Non-autoimmune ... rheumatologic diseases ... disorders (e.g. thyroid ... #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... solid cancers • Autoimmune ... diseases: SLE++ ... treatment #summary #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL: mediastinal mass ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... erythematosus (SLE ... cell lymphoma Pathophysiology ... Histopathological Diagnoses ... #management #rheumatology
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