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differential management antibodies causes oncology activation algorithm ana antinuclear autoantibodies behcet cd4 chronic cll disease diseases erythematosus framework hus icl
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Leukemia, Tumour ... methotrexate) • Drugs Autoimmune ... • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... , autoimmune hepatitis ... microsomal) - Autoimmune ... #diseases #diagnosis ... #table #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... : ITP, HITT - Autoimmune ... : SLE, RA, antiphospholipid ... syndrome - Pregnancy ... #Framework #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
ALL: mediastinal mass ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... #Hematology #Oncology ... #Diagnosis
Thrombotic Microangiopathy - TMAs 1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
triad of MAHA + thrombocytopenia ... . 5. 2nd TMA- autoimmune ... catastrophic APS, SRC, SLE ... Microangiopathy #TMAs #hematology ... #diagnosis #ttp
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Neutropenia, anemia, thrombocytopenia ... • Sezary syndrome ... #diagnosis #workup ... #oncology #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... Thyroid, Autoimmune ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... rheumatologic diseases ... disorders (e.g. thyroid ... Hodgkin lymphoma and leukemia ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Asia • HLA-B51 association ... Oral aphthae : SLE ... tears, Ischemia, Leukemia ... • Arthritis: SLE ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(MAS) Classified ... erythematosus [SLE ... leukopenia, anemia, and thrombocytopenia ... #Diagnosis #Management ... #Hematology #Rheumatology
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