10 results
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... .2015.10.012 #Antifungal ... #antibiogram #management ... #pharmacology #
Invasive Candidiasis (IC)

Diagnosis:
Culture:
 • Gold standard, but Slow (~2-3 days), 50% sensitivity
 • Blood Sample
 •
Invasive Candidiasis ... Tests Conduct antifungal ... #IC #antifungal ... #diagnosis #management ... #candida #auris
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
B for initial management ... - Virtually never ... for non-severe candida ... #Pharmacology #Antibiotics ... #Flutycosine #Antifungal
IDSA Recommendations for Treating Mucosal Candidiasis in HIV-AIDS
Oropharyngeal Candidiasis: Initial Episodes (Duration of Therapy: 7–14 days)
Preferred
Treating Mucosal Candidiasis ... Note: Systemic antifungals ... #candida #mucosal ... Prevention #Treatment #management ... infections #HIVAIDS #pharmacology
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... Cidal vs Candida ... choice for severe Candida ... salvage therapy, never ... Anidulafungin #Pharmacology
Candidemia Workup and Management - IDSA Guidelines
1) Antibiotics
 • Empiric: Echinocandins (e.g. micafungin) for most patients
Candidemia Workup and Management ... Consider: Spine, CNS, liver ... IDSA #Guidelines #Management ... #candida #candidiasis
Candida Glabrata
Species of Candida Most Commonly Isolated in Bloodstream Infections
 • Symptomatic mucosal infection is detected
esophageal, & vaginal candidiasis ... with persistent fever ... unresponsiveness to antifungal ... time to azole antifungals ... #fungemia #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
decrease in HIV-1 RNA level ... Fever, chills, lack ... Parvovirus B19 • Candida ... -6 weeks after antifungal ... Differential #Diagnosis #Management
Overview of antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis.
Fluconazole - Low
Overview of antifungal ... hypokalemia, phlebitis, fever ... #valleyfever #management ... #treatment #antifungals ... comparison #table #pharmacology
Antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis
Fluconazole
 - Benefits: Low cost/tolerable
Antifungal agents ... hypokalemia, phlebitis, fever ... chest/back pain #Antifungal ... Coccidioidomycosis #pharmacology ... #management #treatment