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rheumatology pathophysiology differential lupus autoimmune dermatology disease erythematosus management myositis syndrome systemic behcet classification complications criteria dermatomyositis dm extraarticular giantcell
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Joint Pain Rash ... infection Malar rash ... Hypersensitivity vasculitis ... gangrenosum • IBD ... #differential #diagnosis
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations Risk Factors: - Unclear environmental triggers (may be viral, not
patients < 50 yrs old ... ; F>M Signs/Symptoms ... skin lesions ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... , Vasculitis, Purpura ... (rare), Arthritis ... erythematosus #signs ... #symptoms #diagnosis
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... can present with rash ... Classic triad of ILD ... myositis, and arthritis ... Can also see mechanics
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... mucositis - Rash ... Presentation - Systemic Symptoms ... purpura: strong sign ... , and SLE) • Urinalysis
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Clinical Findings Diagnostic ... • Polymorphous rash ... : - Coronary Arteritis ... - Generalized Skin ... #Symptoms #Vasculitis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
meningitis), MCC CNS symptoms ... Oral aphthae : SLE ... : SLE, Reactive ... #management #signs ... #symptoms #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Presentation: Systemic Symptoms ... purpura: Strong sign ... , mucositis • Rash ... • Progressive symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... inflammation on skin ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis ... #signs #symptoms
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Rheumatoid arthritis ... manifestations Skin ... blood vessels (vasculitis ... pathophysiology #signs ... #symptoms #diagnosis
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