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diagnosis management behavioraldisorder neurology orthopedics syndrome algorithm complications differential treatment biliary cirrhosis endocrinology hepatology mooddisorders pagetsdisease pbc sclerosis summary urology
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
Leukemia) • GI diseases ... liver or kidney disease ... Corticosteroid use • Primary ... #Osteoporosis #pathophysiology ... #signs #symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
: Commonly no signs ... easily/weakness, Bone ... /joint pain Psychiatric ... Symptoms: Disorientation ... Secondary #Tertiary #pathophysiology
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings Pars interarticularis stress fracture (spondylolysis) - most frequently in the
tenderness • Positive one-legged ... XR — scotty dog sign ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology ... #signs #symptoms
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
mechanical loading => Bone ... strain => Bone ... StressFractures #msk ... #orthopedics #pathophysiology ... #symptoms #signs
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
erythematosus (SLE) Signs ... / Symptoms: - ... Sjogrens #Syndrome #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Diagnosis Algorithm Symptoms ... quadrant discomfort Signs ... of autoimmune disease ... Diagnose PBC if 2/3 criteria
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease ... Pathophsiology ... Osteonecrosis, bone ... #Diagnosis #Signs ... #Symptoms
Femoral Head Fracture: Pathogenesis and clinical findings • Posterior hip dislocation -> Impaction force from femoral
tear a portion of bone ... onto lateral hip Signs ... FemoralHead #Fractures #msk ... #diagnosis #pathophysiology ... #signs #symptoms
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Examination: • UMN signs ... Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... rare, gestational diseases ... Signs/Symptoms: ... Pretibial myxedema #Primary ... endocrinology #pathophysiology
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