27 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... use in cellular metabolism ... via anaerobic metabolism ... acidosis including ... LacticAcidosis #Toxicity #Toxicology
Toxic Alcohol Ingestion
Alcoholic ketoacidosis - Methanol - Ethylene glycol - Isopropyl Alcohol
 • Metabolic Acidosis
 •
Isopropyl Alcohol • Metabolic ... Acidosis • Osmolar ... Ingestion #diagnosis #toxicology
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Renal failure • Metabolic ... acidosis • ARDS ... Colchicine #Toxicity #Toxicology
Toluene Poisoning - Diagnosis and Management Summary
What is it?  Volatile hydrocarbon, Glue or paint-sniffing, Occupational
Early raised AG acidosis ... normal anion gap acidosis ... John Booth @ThePeanutKidney ... Toluene #Poisoning #Toxicology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... Labs: Anion-Gap Metabolic ... Acidosis, Respiratory ... Aspirin #Toxicity #Toxicology
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
deterioration Shock and metabolic ... acidosis (12-48 ... - Anion gap metabolic ... acidosis with both ... Poisoning #Toxicity #Toxicology
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte
 - Causes hyperkalemia?
 - Safe to
Causes lactic acidosis ... patients with a metabolic ... acidosis? ... #Crystalloids #pharmacology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
development of metabolic ... acidosis - Protective ... Hyperchloremia nonanion gap metabolic ... acidosis • Saline ... NS #comparison #pharmacology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Clopidogrel (Plavix) and Clopidogrel Non-responders

Clopidogrel is an irreversible selective inhibitor of the platelet low-sensitivity adenosine diphosphate
to its active metabolite ... Nonresponders #pharmacology ... #toxicology