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causes algorithm hus intravascular microangiopathy palpable petechiae petechial thrombotic anemia arterial dic disseminated embolism extravascular hemolysis hemolytic hemolyticuremicsyndrome management microangiopathies
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Nonpalpable purpura ... presents in thrombocytopenic ... rash, the diagnosis ... #Diagnosis #Dermatology ... #Purpuric #Rash
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... of thrombocytopenia ... purpura/hemolytic ... , Hematology 2012 ... #Evaluation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... Diagnosis #hematology ... #dermatology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Microangiopathy #thrombocytopenic ... #purpura #TTP # ... HemolyticUremicSyndrome #HUS #thrombocytopenia ... #Comparison #Diagnosis ... #Table #Hematology
Causes of Purpura - Differential Diagnosis Non-PalpabIe → Palpable • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... → Palpable • Thrombocytopenia ... Coagulation defects ... BrighamChiefs #Purpura ... #nonpalpable #palpable
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis Table ... • Thrombotic Thrombocytopenic ... Purpura (TTP) ... Metabolism-mediated TMA - Coagulation-mediated ... Microangiopathy #TMA #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
hemostasis: - Thrombocytopenia ... Henoch Schonlein Purpura ... : - Purpura fulminans ... deficiency Work ... #Causes #dermatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
transfusion • Thrombocytopenia ... Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... coagulopathy - Thrombocytopenia ... treatment #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
intravascular coagulation ... microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... Extravascular #Causes #differential ... #diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP ... thrombocytopenia ... intravascular coagulation ... other causes of purpura ... pathophysiology #hematology
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