10 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury Hepatocellular ... #Enzymes #LFTs ... #Cholestatic #Transaminitis ... #diagnosis #differential
Evaluation abnormal liver tests in pregnancy
- Cholestatic Pattern
- Hepatocellular Pattern

#LFTs #transaminits #pregnancy #obgyn #obstetrics #hepatology #diagnosis
Evaluation abnormal liver ... in pregnancy - Cholestatic ... Pattern - Hepatocellular ... Pattern #LFTs ... #transaminits #pregnancy
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... ALT ≥ 3x ULN Cholestatic ... ALP) ≥5: Hepatocellular ... #FunctionTest #LFTs ... #Elevation #Transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... Hepatocellular ... Burak @kwburak #LFTs ... #Elevated #Abnormal
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... phosphatase) 2) Cholestatic ... Liver Injury Differential ... hepatology #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - ... Differential Diagnosis ... #Differential # ... Diagnosis #hepatology #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Calculate R-Value • Hepatocellular ... Mixed DILI • Cholestatic ... Idiosyncratic #differential
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Thrombosis, Emboli Hepatocellular ... specificity to elevated ... ALP: Typical of hepatocellular ... injury #hepatitis #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential ... • Others • Cholestatic ... • Others #LFTs ... #LiverEnzymes #Differential