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diagnosis hepatology algorithm enzymes hepatocellular abnormal acidosis causes chemistry cholestatic classification dehydrogenase elevated function functiontest hepatitis interpretation lactic ldh patterns
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... • AST/ALT elevation ... #Cholestatic #Transaminitis ... #diagnosis #differential
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... Hepatocellular injury ... 2: Cholestatic injury ... #FunctionTest #LFTs ... #Elevation #Transaminitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... injury) • Ischemic ... #Differential # ... Diagnosis #hepatology #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... #Injury #Differential ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... #Patterns #Liver ... #LFTs #transaminitis ... #differential #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... or renal injury ... - assess other laboratory ... Injury: • Reduced ... #Differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... Idiosyncratic LDH Elevation ... #diagnosis #Laboratory
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... magnitude of enzyme elevation ... normalised ratio; LDH, lactate ... #LFTs #Abnormal ... #Enzymes #Differential
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