35 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... • NAFLD • Cirrhosis ... injury) • Ischemic ... #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminases / Transaminitis ... - Differential Diagnosis ... Trauma: Shock liver ... • Autoimmune hepatitis ... #causes #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
B - Diagnosis and ... viremia or have cirrhosis ... HAV immunity; Liver ... #Diagnosis #Management ... #Treatment #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... Infections: Hepatitis ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... injury (INR > 2 ... #HepBV #HBV #Treatment ... #Indications #management ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... #Cholestatic #Transaminitis ... #diagnosis #differential ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... non-essential drug/HDS treatments ... , HBV, HCV, HEV, ... #Injury #Diagnosis ... #Algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Injury (DILI) ... Viral Hepatitis ... #Hepatology #gastroenterology ... #management #diagnosis
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... Hepatocellular injury ... #FunctionTest #LFTs ... #Elevation #Transaminitis ... #diagnosis #hepatology