862 results
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
TRALI vs TACO - Transfusion ... plasma volume transfusion ... blood donor • Pathophysiology ... Within 6 hours of transfusion ... • Pathophysiology
Hydroxyurea - Pathophysiology and Benefits in Sickle Cell Disease
 • Decreases number of pain crises (
Hydroxyurea - Pathophysiology ... 24%) • Fewer transfusions ... Benefits #SickleCell #pathophysiology
Classification of COVID-19 Disease States and Potential Therapeutic Targets

Viral Response Phase -> Host Inflammatory Response Phase
Stage
convalescent plasma transfusions ... Classification #Diagnosis #Pathophysiology
Babesiosis - Babesia Life Cycle
1) Tick takes a blood meal (sporozoites introduced into host)
2) Trophozie ←→
human-to-human via blood transfusion ... LifeCycle #diagnosis #pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Diuretics, PRBC transfusion ... Lysis Syndrome: • Pathophysiology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... consider platelet transfusion ... Pressure #ICP #Pathophysiology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Evidence Summary for Transfusion ... show that PRBC transfusions ... Unnecessary transfusions ... Transfusions should ... Transfusions are
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
incompatible blood transfusion ... protein C and S Pathophysiology ... hydration • RBC transfusion
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
destruction after transfusion ... Classification #Pathophysiology
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Framework NCPE Pathophysiology ... pulmonary edema) • Transfusion-related