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diagnosis differential intravascular oncology treatment aplastic arterial coagulation common cvid dermatology dic disseminated embolism extravascular hemeonc hemolysis hemolytic hemophagocytic hlh
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... • Mechanical Trauma ... ) - HELLP syndrome ... differential #diagnosis #hematology ... #anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #treatment #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... Kasabach-Merritt syndrome ... Solar purpura - Trauma ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Constitutional Syndromes ... #oncology #hematology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Surgery • Trauma ... • Nephrotic Syndrome ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Recent history of trauma ... protein C and S Pathophysiology ... Treat primary cause ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... Presentation • Common Signs ... - Cytopenias (anemia ... Pathophysiology ... #Hematology #HemeOnc
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