18 results
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Platelet Count ... Non-infectious (malignancy, rheumatologic ... , trauma) • Post-splenectomy ... #causes #Platelets ... #hematology
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet ... TEG #Management #treatment ... #diagnosis #hematology
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet ... TEG #Management #Diagnosis ... #Hematology #Thromboelastogram ... #Treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... → Refer to hematology ... Rebound effect from treatment ... Thrombocytosis #Platelets ... #Algorithm #hematology
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
fibrin clot - Treatment ... representing thrombin-platelet ... : Platelets, DDAVP ... Thromboelastography #diagnosis ... #coagulation #hematology
PLATELETS Mnemonic for Causes of Thrombocytopenia

P - Platelet Disorders (DIC, ITP, TTP)
L - Leukemia, Lymphoma
A -
PLATELETS Mnemonic ... Thrombocytopenia P - Platelet ... Aplastic Anemia T - Trauma ... S - Sepsis #PLATELETS ... #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Purpura (TTP) Diagnosis ... secondary TMA), Platelets ... Contraindication to platelets ... #rheumatology # ... hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
RBC's secondary to platelet ... Thrombocytopenia • Platelet ... NON-PALPABLE PURPURA: Platelet ... Solar purpura - Trauma ... #hematology #rheumatology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Laboratory • Normal platelet ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
bleeding from low platelets ... Symptomatic anemia Diagnosis ... megaloblastic anemia Treatment ... #management #treatment ... #hematology