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hematology management algorithm differential leukemia mds myelodysplastic anemia anticoagulation antiphospholipid aplastic cancer chronic cll comparison cppd differentiation immune inflammatory iris
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... Antiphospholipid antibodies (aPL ... to be present Treatment ... (EULAR Guidelines ... #APS #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... #APML #diagnosis ... #oncology
Approach to Gout Diagnosis: r/o septic arthritis! Needle-shaped, negative birefringent crystals Treatment: • Weight loss, diet, d/c culprit
Diagnosis: r/o ... diet, d/c culprit medications ... • Acute: NSAIDs ... • Colchicine: Acute ... #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... transformation to acute ... only curative treatment ... #Management #treatment ... #hematology #oncology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... #Differential #Diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... ALL can present as ... smear: Blasts APML ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
Gout - Diagnosis ... sex • Metabolic syndrome ... • Medications ... gout treatment; ... #treatment #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... , AKI, acute limb ... organ damage • Treatment ... #TLS #diagnosis ... #management #hematology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
calcification appears as ... • Metabolic syndrome ... • Medications ... #Comparison #rheumatology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... • Richter’s Syndrome ... ’s lymphoma or acute ... #workup #oncology ... #hematology
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