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diagnosis biliary lfts management pbc primary syndrome transaminitis apml causes cholangitis differentiation function hemeonc hemophagocytic hepatorenal hlh hrs injury lymphohistiocytosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... 500-1000): • Genetic ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... Methotrexate Genetic ... Nonalcoholic fatty liver ... #Diagnosis #Differential ... #Hepatology #Cirrhosis
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 Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... Smoking, Microbial triggers ... DNA methylation Genetic ... Primary #Biliary #Cirrhosis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... Hemolysis, NASH, Genetic ... #Injury #hepatology ... transaminitis #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... /Liver failure ... or higher • Liver ... bile ducts Differential ... diagnosis #workup #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... initiation • Differential ... organ dysfuxtion, ICU ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
(or triggers) is ... Familial) HLH: - Genetic ... - Elevated liver ... Pathophysiology ... Diagnosis #Management #Hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Occurs in advanced liver ... disease: cirrhosis ... Pathophysiology: ... Norepinephrine (ICU ... Hepatorenal #Syndrome #Hepatology
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