Trigger pathophysiology differential peds hepatology syndrome anemia thrombocytopenia diagnosis

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Implicated as Triggers ... of Drug Induced Thrombocytopenia ... #Diagnosis #Hematology ... #Thrombocytopenia ... #Differential #

Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film.
TTP/HUS indicates thrombotic

for workup of thrombocytopenia ... hemolytic uremic syndrome ... , Hematology 2012 ... , p 193 #Diagnosis ... #Differential #

Causes of Thrombocytopenia - Differential Diagnosis Algorithm

Decreased Megakaryopoiesis
• Aplastic Anemia
• Toxic Damage (e.g.

- Differential ... Diagnosis Algorithm ... Megakaryopoiesis • Aplastic Anemia ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology

Red Blood Cell (RBC) Morphology Atlas
• Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning

Myelodysplastic syndrome ... Thrombotic idiopathic thrombocytopenia ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology

Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm
Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome
Indirect Hyperbilirubinemia:
- Trauma, Hematoma,

Hyperbilirubinemia - Differential ... Diagnosis Algorithm ... , Crigler-Najjar ... #Diagnosis #Algorithm ... #hepatology

Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
• Hemolysis
• Ineffective Erythropoiesis
• Hematoma
Decreased

Jaundice - Differential ... Diagnosis Algorithm ... • Crigler-Najjar ... Syndromes (l and ... #Causes #Hepatology

Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
• Artifact (redo CBC)
Autonomous:
• Essential thrombocytosis
• Polycythemia

Thrombocytosis - Differential ... Diagnosis Algorithm ... following EtOH induced thrombocytopenia ... Iron deficiency anemia ... #Causes #Hematology

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia

Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
- Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,

Causes of Thrombocytopenia ... - Differential ... Diagnosis Framework ... antiphospholipid syndrome ... #hematology

Causes of Depressed / Lethargic Newborn - Differential Diagnosis Algorithm
Maternal Related:
• Drugs (Ex. SSRI)
•

Lethargic Newborn - Differential ... Diagnosis Algorithm ... Respiratory Distress Syndrome ... Sepsis Other: • Anemia ... #Causes #Peds #

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